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The 22-50BMG = OverBore 😉
I’d say that it is a relative term when compared to the 30-06 as a standard.
25-06 marginal, 257 Wby = overbore
All the new 26, 27, 28 Noslers = overbore
375 and 416 Ruger, all perfectly fine.
416 Wby, over the line.
I’d say as long as you’re aware of the potential for reduced barrel life, then go have some fun. Then when it’s time, just have Tim set it back a thread or two and go some more.
just my .02