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At one point I took a muzzle loader, a (CVA SxS .50) and harvested a 4 point buck with my own .45acp hardball HP’ed with a lathe center drill.
Shot it out of a .45/.50 sabot.
I did not recover the bullet, but it did pass all the way thru, and left bigger than it went in.
He went down like a sack of potatoes, and stayed there.